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What is FAVA?

A fibro-adipose vascular anomaly (FAVA) is a rare vascular anomaly occurring when the body’s own tissue infiltrates a muscle, creating a tumor-like mass typically found in one or more limbs.  


We all have fibrofatty tissue - called adipose tissue - in our bodies.  Adipose tissue serves the important function of storing fat.  And we all have muscles in our extremities – our arms, hands, legs, and feet.  Our muscles are made up of collections of muscle cells called muscle fibers, along with blood vessels, tendons, and nerves.  The current hypothesis among experts is that in a patient with a fibro adipose vascular anomaly, one or more of the muscle fibers in an extremity have been replaced at birth with adipose tissue.  Unlike cancer, the mass of adipose tissue does not destroy the healthy muscle tissue surrounding it.  Rather, the adipose tissue grows and infiltrates the muscle tissue, as well as often infiltrating the blood vessels, tendons, and nerves.  In fact, the adipose tissue tends to take over the entire muscle, causing swelling and, due to the infiltration of nerves, significant pain.  While this theory is supported by little scientific investigation, it nonetheless constitutes the best current explanation of FAVA growth and correlating pain.  If a FAVA has a significant venous component, pain may also be caused by swelling and inflammation of the vein (phlebitis/phlebectasia).    


In FAVA patients, the adipose mass grows more rapidly than the extremity where it is located.  The rate of growth varies among FAVA patients, and its pattern of growth is not yet fully understood.  Nonetheless, it is currently believed FAVA does not spread within the body beyond the affected muscle(s).  


The cause of FAVA is unknown.  However, it is believed that in at least some patients, it involves a mutation of the PIK3CA gene, which is a gene involved in - among other things - regulating cell growth, division, movement, survival, and metabolism.  The mutation causing FAVA is a somatic mutation, meaning that it cannot be passed down to your children.     

​Fibro-adipose vascular anomaly (FAVA) is a relatively new term.  FAVA was first recognized as its own disorder in 2014.  Prior to that, patients with FAVA were incorrectly diagnosed with a variety of vascular malformations.  Even today, many FAVA patients are misdiagnosed with venous malformations, hemangiomas, arteriovenous malformations, lymphatic malformations, and other vascular anomalies.    

Learn more about FAVA with this downloadable educational brochure.


This content was created for general informational and convenience purposes only. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking advice because of something you have read on this website.

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Photo courtesy of Pexels 

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